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Compared with GLP-1 RAs, more participants receiving tirzepatide 15 mg discontinued treatment due to adverse events (OR 2.29 [95% CI 1.39, 3.75], I 2 0%), whereas no difference was evident for tirzepatide 5 mg and 10 mg (ESM Table 3)

The dysfunction of hematopoietic stem and progenitor cells drives inflammation-related myelopoiesis, which maintains neutrophil populations and promotes chronic inflammation [126]

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